Meh, hype yourself up on several bottles of coke, some No-Doz, sit through a David Lynch marathon then polish it off with the movie "The Ring" to explain how you just f***ed it all up.
I look at it this way...If the paranoia involves a supernatural theme it's actually an entertaining challenge but if it involves a down to earth situation where you suspect that someone is out to thug you that's a bit more frustrating because your opponent in that instance is an utter waste of space and if they pull the trigger before you do - not only did their useless existence end yours but also ended any good you could've done for people in your life. Also consider that if you pull the trigger first your going to wind up in jail.
And putting it in perspective - One is like dying in an honorable battle with another samurai while the other is just getting murdered by someones stupid dog that got lose.
And thirdly..if the paranoia is a chic...you should have several of those on hand at all times anyway.
Oh, and finally...if it involves a health complication...I think I've proven to myself now that most illnesses can be remedied by simply forgetting I have them. And I'm not referencing hypochondria...I think a lot of people who recover from cancer do so by not focusing on it during the time its there.